Koide Laboratory - Synthetic Protein Science

We aim to advance the knowledge of how proteins and protein interaction networks work by “synthetic” approaches, i.e. designing and making proteins with novel function.  This "learning by building" approach critically tests our understanding of principles that govern protein structure, function and evolution, and it challenges our creativity.

We are now capable of producing highly functional synthetic proteins within weeks.  Structural and functional analysis of synthetic proteins not only critically evaluates the effectiveness of our design strategies but also provides broader insights into the molecular mechanism and evolution of protein form and function.  Knowledge gained from the synthetic approach complements and very often significantly expands the view from classical studies of natural proteins.

Synthetic proteins serve as novel and transformative tools for basic and translational research in medicine and beyond.  We are particularly interested in applying our capability to:

  • Development of biologics therapeutics (engineered proteins and antibodies)
  • Signal transduction and cancer biology
  • Epigenetics
  • Structural biology
  • Synthetic biology

Why synthetic protein science?


September 2017 - Gabe's paper on monobodies that activate or inhibit GPR56 is published in PNAS.

July 2017 - Gabe successfully defended his Ph.D. Congrats Dr. Salzman!

May 2017 - Our first anniversary at NYU Langone Medical Center. Publication list updated.

March 2017 - Our review on Monobody and other synthetic binding proteins is published in Protein Science (open access).

March 2017 - Our paper on Monobodies to the Src branch of SH2 domains is published in J Mol Biol (open access)

November 2016 - Our paper on RAS-inhibiting monobody is published in Nature Chemical Biology.

October 2016- Our paper on the NMR structure of a highy aromatic novel fold is published in Protein Science.

October 2016 - Our paper on a collaborative project on histone chaperone sNASP is published in Nuclec Acids Research.

September 2016 - Gabe's paper on GPR56 structure and antagonistic monobody is published in Neuron.

May 2016 - After 14 years at the University of Chicago, the Koide lab has relocated to New York University School of Medicine in Manhattan, New York.